Overall, the sentiment towards Mortal Sin is largely positive, with players frequently mentioning the engaging melee combat and visually unique style. The developer's dedication and frequent updates are highly praised, contributing to the game’s positive reception. However, some players are critical of the visual style for its potential to cause eye strain, and express concerns over difficulty spikes and repetitive elements. The combo system is also a subject of debate, with some finding it rewarding and others less intuitive. Despite these criticisms, the game is often recommended for fans of challenging rogue-likes.