Overall, Slay the Spire is immensely appreciated by players for its deep, strategic gameplay and vast replayability. While it has a steep learning curve and can sometimes feel too reliant on RNG, the game's challenging nature is often seen as rewarding. It caters to a wide audience through its simple yet deep mechanics, charming art style, and supportive modding community. Despite some minor criticisms, it's heralded as a paragon in the roguelike deck-builder genre, with many looking forward to its sequel.